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Dr Adam Rutherford and guests explore the scientific mysteries of the menopause after scientists in the US and Japan successfully induced pregnancy in post-menopausal women.

Also in the programme, we hear from decision scientist Baruch Fischhoff on the difficulties of trying to communicate uncertainty in science in the wake of the latest report from the Intergovernmental Panel on Climate Change. Following on from last week's Fracking report, one listener, Professor Kevin Anderson of the University of Manchester, raises his concerns about the consequences of exploiting shale gas for UK carbon emissions.

This week's show us your instrument comes from the Rutherford Appleton Laboratory in Oxfordshire, where Dan Faircloth tends to the ISIS particle accelerator.