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In the second episode, Vicky sets out to see the impact of music on people in the later stages of dementia. She visits a care home offering music therapy and sees how their unique approach is benefiting the people there. Four choir members take part in an unprecedented experiment when they are scanned at the University of Nottingham to see how the different parts of their brains communicate when listening to music despite the damage caused by their dementia.

The three-month scientific study to see whether singing in the choir has any measurable physiological effect on them comes to an end, and Vicky announces that in a matter of weeks they are going to perform at the Royal Concert Hall in Nottingham in front of an audience of 2,000 people. However, it鈥檚 not long before the very real challenges faced daily by the choir threaten to derail the entire project as members struggle to learn the new songs. With Vicky and choir master Mark De-Lisser driving them forward, can they pull it off?