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24-year-old Carys has endured a constant cycle of illness for the last nine years. She suffers with headaches, nausea and vomiting, repeated infections and a constant fever. Over the years, Carys has seen numerous specialists, but no-one has come up with a satisfactory explanation for her symptoms. After examining her medical records, three of the experts are keen to take on Carys鈥檚 case. However, during an initial consultation, a surprising new symptom is discovered, sending their investigation in another direction.

While the team begin their detective work on Carys's case, Michael introduces them to another patient who is desperately searching for answers. 43-year-old army veteran Andrew suffers up to 50 unexplained seizures every week, and it is having a devastating effect on his life. After discussing his medical records with the team, consultant cardiologist Dr Boon Lim and consultant neurologist Dr Paul Jarman have very different theories about what might be causing Andrew鈥檚 dramatic seizures.