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The Sackler name is more often associated with philanthropy and lavish donations in the arts and sciences. But the investigative reporter Patrick Radden Keefe tells another story in Empire of Pain. He questions how much of the Sackler wealth was made from the making and aggressive marketing of the painkiller, Oxycontin. He tells Amol Rajan of the misery that has unfolded in today’s opioid crisis – an epidemic of drug addiction which has killed nearly half a million people in the US.

The direct marketing to GPs and advertising campaigns in the US helped to make Oxycontin a hugely popular drug. But in the UK too there are concerns about the over-prescribing of painkillers for long periods of time. Dr Zoe Williams is a GP in South London and presenter of the ³ÉÈËÂÛ̳ show, Trust Me I’m a Doctor. As a founding member of the British Society of Lifestyle Medicine she’s pioneering changes to reduce dependency on drugs, and increase take-up of alternative treatments, like exercise.

What happens when people start to mistrust medical authorities is at the heart of Heidi Larson’s work as Director of the Vaccine Confidence Project at the London School of Hygiene & Tropical Medicine. In her latest book, Stuck, she looks at how vaccine reluctance and refusal is no longer limited to the margins of society. As mistrust of the official message and messenger grows so does rumour, conflict and hesitancy.

Producer: Katy Hickman