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DNA structure

The structure of DNA

James Watson and Francis Crick worked out the structure of in 1953. By using data from other scientists (Rosalind Franklin and Maurice Wilkins) they were able to build a model of DNA. The X-ray crystallography data they used showed that DNA consists of two strands coiled into a .

Image gallerySkip image gallerySlide 1 of 2, An x-ray diffraction photograph of DNA, The famous X-ray diffraction photograph of DNA taken by Rosalind Franklin, known as photograph 51.

DNA is a polymer made from four different . These are arranged in a repeating fashion. Each nucleotide consists of alternating sugar and phosphate sections with one of the four different bases attached to the sugar.

A visual to describe the base pairs in DNA.

Base pairs

Each strand of is made of chemicals called bases. Note that these are different to bases in relation to acids and alkalis in chemistry.

There are four different bases in DNA:

  • thymine, T
  • adenine, A
  • guanine, G
  • cytosine, C

There are chemical cross-links between the two strands in DNA, formed by pairs of bases. They always pair up in a particular way, called complementary base pairing:

  • thymine pairs with adenine (T-A)
  • guanine pairs with cytosine (G-C)
DNA strand showing bases pairs: TA, GC, AT repeated randomly.
Figure caption,
Base pairs on a section of DNA

A sequence of three bases is the code for a particular amino acid, which is known as a triplet or the triplet code. The order of the bases controls the order in which amino acids are assembled to produce a particular protein.